603 papers
This study demonstrates that the specific route to whole-genome duplication critically determines nuclear stability, revealing that mitotic slippage uniquely induces nuclear instability through altered chromatin compaction and mechanical softness, whereas other mechanisms like cytokinesis failure and endoreplication preserve nuclear architecture.
Using high-throughput single-cell imaging, this study demonstrates that Topologically Associating Domain (TAD) boundary architecture and gene activity are largely uncoupled, as TAD boundary interactions are infrequent and independent of transcriptional status, while disrupting TAD boundaries does not alter gene expression.
This study reveals that the small heat shock protein HSPB8 regulates CTP synthase filament dynamics by clearing misfolded proteins to restore catalytic activity, thereby coupling nucleotide metabolism with autophagic flux to support tumor survival under nutrient stress.
This article reviews the formation and structure of Envelope-Limited Chromatin Sheets (ELCS) in retinoic acid-induced HL-60/S4 granulocytes, highlighting the critical role of increased Lamin B Receptor (LBR) synthesis and cholesterol biosynthesis in creating these flexible nuclear outgrowths, while contrasting these features with the lack of ELCS and reduced LBR in phorbol ester-induced macrophages.
This study reveals that epithelial monolayers utilize a mechanical memory of confinement pressure to coordinate collective growth, ensuring that tissues starting from diverse initial densities and cell numbers robustly converge to the same final homeostatic size and density upon expansion.
This study identifies the disruption of the endocytic AP2 complex as a common upstream mechanism by which diverse NLRP3 activators impair plasma membrane signaling, thereby triggering inflammasome activation and cell death.
This study demonstrates that in *Ashbya gossypii*, the specific sequence and structural context of RNA-protein binding sites, rather than just their number (valence), critically determine the physical properties and biological function of biomolecular condensates.
This study identifies *Plasmodium falciparum* SR12 as a GOLD-domain seven-transmembrane protein that structurally resembles mammalian GOST proteins and functions as a chaperone to promote GPCR trafficking to the plasma membrane in mammalian cells.
This study reveals that coding RNAs drive the phase separation of synapsin-1 to organize presynaptic vesicle clusters and create a specialized platform that enhances local protein translation at nerve terminals.
This study utilizes mass spectrometry to demonstrate that the extreme anoxia tolerance of *Austrofundulus limnaeus* WS40NE cells is supported by dynamic changes in both histone post-translational modifications and histone isoform abundance during oxygen deprivation and recovery.
This study identifies a novel mechanism where platelets utilize actomyosin-driven swirling motions to actively wind and compact fibrin fibers into dense structures, thereby reducing clot volume and enhancing wound repair.
This study demonstrates that Tel1-mediated localized negative feedback, acting through Xrs2-dependent recruitment and kinase activity, reshapes the genome-wide landscape of meiotic DNA double-strand breaks by redistributing them based on innate chromosome-specific patterns, thereby influencing genetic variation.
This study introduces a coculture assay demonstrating that the intercellular transfer of extracellular vesicle markers CD63, CD9, and CD81 is spatially polarized, occurring more efficiently at short distances and in basal planes, while distinguishing between migration-associated membrane remnants and active secretion in upper planes.
This study identifies the N-degron pathway as a key mechanism for clearing hereditary transthyretin amyloidosis aggregates and demonstrates that the AUTOTAC-based degrader ATC201 effectively reduces TTR burden and ameliorates disease symptoms in cellular and mouse models by targeting these aggregates for p62-mediated autophagic degradation.
This study demonstrates that the small-molecule autophagy activator AUTEN-99, but not AUTEN-67, effectively improves survival and cellular responses in glia-specific models of Spinocerebellar ataxia type 1, highlighting its potential as a therapeutic agent for neurodegenerative diseases.
This study reveals that unlike in mice, human aging and Alzheimer's disease involve an adaptive regulation of ribosomal error rates mediated by ER-stress signaling and Alzheimer's-related proteins, highlighting translation fidelity as a critical factor in human proteostasis and neurodegeneration.
This study reveals that global histone deacetylation during apoptosis compacts fragmented chromatin through electrostatic attraction, thereby preventing the release of DNA into extracellular vesicles and ensuring the safe clearance of dying cells.
This study reveals that metabolic stress induces the widespread accumulation of functional, cap-unmethylated mRNAs in yeast and mammals, demonstrating that cap methylation is a dynamic, regulated modification linked to H3K36me3 that confers an adaptive advantage during stress rather than being a constitutive feature of mRNA.
This study reveals that macrophages recruit membrane-bound DNaseX to nascent phagocytic cups to degrade extracellular DNA prior to phagosome closure, establishing a novel mechanism for clearing bulky eDNA structures without internalization.
This study demonstrates that restoring ribosomal homeostasis by targeting the RNAse P/MRP complex or mitochondrial ribosome, rather than merely reducing translation, corrects age-associated defects in ribosome biogenesis and assembly to improve proteostasis and extend lifespan in *C. elegans*.