414 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study presents a human embryonic stem cell toolkit lacking 23 lysosomal storage disorder genes, coupled with multi-omics analyses and cryo-electron tomography, to define distinct proteomic signatures, mitochondrial vulnerabilities, and synaptic defects in cortical and dopaminergic neurons.
This study reveals that single-cell variability in hormone response magnitude within mammary organoids and human ERα+ cancer cells is driven not by receptor abundance alone, but by the balance of transcriptional co-regulators and distinct activation kinetics.
The study demonstrates that CAP-1902, a novel MasR agonist, acts as a mitophagy inducer that enhances mitochondrial turnover by activating the AMPK/ULK1/FUNDC1 pathway and stimulating biogenesis, thereby rescuing bioenergetic defects and reducing the integrated stress response in human fibroblasts with Complex III deficiency.
This study demonstrates that nucleus-scale concave microcavities, which mimic the bone microenvironment, induce adaptive nuclear rounding, chromatin compaction, and selective YAP/TAZ-mediated mechanotransduction in human osteosarcoma cells without triggering inflammatory or apoptotic pathways.
This study reveals that miR-378a and NPNT coordinately regulate podocyte autophagy through distinct mechanisms, with miR-378a enhancing flux via mTOR inhibition and NPNT modulating it through MAPK-dependent signaling, offering new insights into the molecular drivers of glomerular diseases.
This study identifies N-acylphosphatidylethanolamines (NAPEs) as endogenous regulators that inhibit LRRK2 kinase activity to restore lysosomal homeostasis and clear alpha-synuclein aggregates, revealing a promising metabolic axis for Parkinson's disease therapeutics.
This study identifies the depletion of bis(monoacylglycero)phosphate (BMP) and the accumulation of its precursor lysophosphatidylglycerol (LPG) as universal, clinically accessible biomarkers for CLN5 Batten disease, confirming CLN5's role as the essential lysosomal BMP synthase and enabling early diagnosis and patient screening via plasma and dried blood spots.
This study identifies Drak as a potential binding partner of Drosophila Filamin that interacts with its mechanically activated conformation and partially colocalizes during embryonic cellularization and flight muscle development, although a direct functional correlation between the two proteins could not be established.
This study reveals that the splicing activator U2AF2 promotes intron retention in lncRNAs PURPL and MALAT1, a mechanism essential for their nuclear localization and the subsequent regulation of cell proliferation and migration.
The paper introduces SCALE, a scalable foundation model for virtual cell perturbation prediction that integrates a high-throughput BioNeMo framework, a stable conditional transport architecture with LLaMA-based encoding, and biologically faithful evaluation metrics to overcome existing bottlenecks in efficiency, stability, and biological fidelity.